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KMID : 1134819990280030625
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Journal of the Korean Society of Food Science and Nutrition
1999 Volume.28 No. 3 p.625 ~ p.631
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Effects of Safflower Seed(Carthamus tinctorious L.) Powder on Lipid Metabolism in High Fat and High Cholesterol - Fed Rats
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Kim Jun-Han
Jeon Seon-Min
Park Young-Ae
Choi Myung-Sook
Moon Kwang-Deog
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Abstract
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A study was carried out to investigate the effects of safflower seed powder on the improvement of lipid metabolism in high fat and high cholesterol-fed rats. Male Sprague-Dawley rats of 10 weeks old, weighing 325±5g, were divided into two groups; the control group(C group, high fat(10% lard) and high cholesterol(1% cholesterol)) and safflower seed group(S group, 10% safflower seed powder), they were fed experimental diets for 6 weeks. Food intake, body weight gains and organ weight had little differences between the groups. Concentration of β-lipoprotein in serum was remarkably lower in S group than in C group. Serum cholesterol levels were significantly lower in S group(72.94±4.08㎎/dl) than in C group(89.41±4.19㎎/dl). The level of serum HDL-cholesterol was higher in S group than in C group. The level of serum LDL-C was significantly lower in S group than in C group. The ratio of HDL-cholesterol to total cholesterol were higher in the S group than in the C group, too. The value of atherogenic index(AI) was determined to be low in S group. The content of liver triglyceride and cholesterol in the S group was lower than that of C group. ACAT activities which involves in cholesterol esterification in liver, was not significantly different between two groups.
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KEYWORD
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safflower seed, lipid metabolism, high fat and high cholesterol-fed rats
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